The 2.4-liter I4 automatic-equipped TSX is the most fuel-efficient Acura for the 2012 model year, with EPA mile per gallon (MPG) ratings of 22 city / 31 highway / 26 combined. The 3.7 liter V6 all-wheel-drive MDX is the least fuel efficient in the range, with ratings of 16 city / 21 highway / 18 combined. Although it is not required, Acura recommends premium fuel for all of the vehicles for optimum performance.
(2013 Acura TSX show below.)
2012 Acura Gas Mileage Table
| Year | Manf. | Model | Disp. | Engine | Trans. | City | Highway | Combined | Drive | Fuel |
| 2012 | Acura | MDX 4WD | 3.7 liter | 6 cylinder | Auto (S6) | 16 | 21 | 18 | AWD | P |
| 2012 | Acura | RDX 2WD | 2.3 liter | 4 cylinder | Auto (S5) | 19 | 24 | 21 | 2WD-F | P |
| 2012 | Acura | RDX 4WD | 2.3 liter | 4 cylinder | Auto (S5) | 17 | 22 | 19 | AWD | P |
| 2012 | Acura | RL | 3.7 liter | 6 cylinder | Auto (S6) | 17 | 24 | 20 | AWD | P |
| 2012 | Acura | TL 2WD | 3.5 liter | 6 cylinder | Auto (S6) | 20 | 29 | 23 | 2WD-F | P |
| 2012 | Acura | TL 4WD | 3.7 liter | 6 cylinder | Auto (S6) | 18 | 26 | 21 | AWD | P |
| 2012 | Acura | TL 4WD | 3.7 liter | 6 cylinder | Manual (M6) | 17 | 25 | 20 | AWD | P |
| 2012 | Acura | TSX | 2.4 liter | 4 cylinder | Auto (S5) | 22 | 31 | 26 | 2WD-F | P |
| 2012 | Acura | TSX | 2.4 liter | 4 cylinder | Manual (M6) | 21 | 29 | 24 | 2WD-F | P |
| 2012 | Acura | TSX | 3.5 liter | 6 cylinder | Auto (S5) | 19 | 28 | 23 | 2WD-F | P |
| 2012 | Acura | TSX WAGON | 2.4 liter | 4 cylinder | Auto (S5) | 22 | 30 | 25 | 2WD-F | P |
| 2012 | Acura | ZDX 4WD | 3.7 liter | 6 cylinder | Auto (S6) | 16 | 23 | 19 | AWD | P |
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– by Daniel Gray